Born in 1962, Colombo graduated with highest honors from the Giuseppe Verdi Conservatory in Milan where she studied with Lino Brandolini. She continued her studies at the European Academy of Music, where she studied with Maestro Massimo Data. Colombo began her career with the Garbarino Ensemble, with whom she played in most of the major Italian venues. She appeared as a solo bassoonist on recordings with the Harmonia Ensemble, and has performed with the Harmonia Ensemble in the most important Italian music festivals. She also joined them on tour in Japan. Colomobo has performed as a soloist in the Sala Verdi in Milan with the Tactus Ensemble and the Pomeriggi Musicali Orchestra, with the University Concerts in Rome, with the Vienna Musikverein, the Archipel Festival in Ginevra, and for La Scala.

In 2005 she soloed on Vivaldi’s “La Notte” with the Italian Swiss Soloists Group at the Palazzo dei Congressi in Lugano. Colombo has collaborated with such noted orchestras as the RAI Symphony Orchestra, the Bolzano Haydn Orchestra, the Swiss Italian Orchestra, Pomeriggi Musicali Orchestra in Milan, Milano Classica Orchestra, and the Angelicum Orchestra.
She currently performs with the Divertimento Ensemble contemporary music group in Italy.

She has recorded with BMG, Stradivarius, De Haske, Amadeus, and Ricordi, and won the 2004 Prix Suisse with the Andersen wind quintet.
Colombo teaches bassoon at the International Academy of Music in Milan, and for Music Together at the Civic School of Lugano.